2022 Fiscal Year Final Research Report
Analysis of inflammation-induced colon cancer development mechanism by adhesive invasive Escherichia coli (AIEC) related molecule
| Project/Area Number |
20K09114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
溝口 恵美子 久留米大学, 医学部, 教授 (40782157)
角田 俊之 福岡大学, 医学部, 准教授 (70444817)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 潰瘍性大腸炎 / 癌化 / CEACAM6 / CH3L1 / CLDN2 |
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| Outline of Final Research Achievements |
We have demonstrated that CEACAM6, CHI3L1, and CLND2 genes, which involved Adherent Invasive E. coli (AIEC), were identified by cDNA microarray analysis derived from resected specimens of normal, inflamed, and cancerous lesions of multiple cancer-complicated ulcerative colitis (UC) patients. For the first time in the world, we reported the relationship between these genes and Colitis-Associated Cancer (CAC). (Kinugasa T. et.al: Anticancer Research, 42 4119-4127; 2022)
It is possible that these expressions are strongly involved in the mechanism of CAC development in UC patients, and development of clinical applications such as innovative diagnostic and therapeutic methods is expected.
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| Free Research Field |
炎症性腸疾患における基礎的解析
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| Academic Significance and Societal Importance of the Research Achievements |
潰瘍性大腸炎(UC)患者の切除組織を用いた今回の検討で抽出された CEACAM6、CH3L1、CLDN2 なども接着性侵襲性大腸菌(AIEC) の活動に関わっていることが分かった。AIECはクローン病患者の炎症が悪化した腸管の環境下に発現が増強する蛋白質である。また、CH3L1 はTNFαやINFγなどの炎症性サイトカインを誘導するため、ポジティブフィードバック因子の可能性が示唆された。以上のことから、これらの発現はUC患者に対するColitic Associated Cancerの早期診断・治療など臨床応用への展開できることが期待される。
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