2022 Fiscal Year Final Research Report
Development of oxygen added DLC coating artificial vascular graft for dialysis shunt
| Project/Area Number |
20K09126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55030:Cardiovascular surgery-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中谷 達行 岡山理科大学, フロンティア理工学研究所, 教授 (50520920)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Diamond-like Carbon / ナノテクノロジー / 生体適合性 / 医療機器 / 異物界面 / 抗感染性 / 人工血管 / カテーテル |
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| Outline of Final Research Achievements |
Carboxylated Diamond-like carbon （C-DLC) was obtained with CVD method using oxygen plasma post-treatment. Then, appropriate setting for C-DLC coating on ePTFE surface was determined. The generated C-DLC coating was confirmed with NEFXAS analysis, RBS spectrum, and ERDA spectrum. In addition, hardness, elasticity, hydrophilicity, and ze-ta potential of C-DLC surface was evaluated. Significant changes of these measurements were observed and increased oxygen content in DLC was also confirmed. We evaluated hemocompatibility of generated C-DLC surface, but C-DLC was not suitable for artificial vascular graft because it was much thrombogenic, not hemocompatible. However, we found that C-DLC has some antibacterial effects with some bacteria.
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| Free Research Field |
心臓血管外科
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| Academic Significance and Societal Importance of the Research Achievements |
DLCにカルボキシ基導入が可能となった。正確にはカルボキシル基のみではなく、C-O結合、C=O結合の増加、酸素含量の増加であるが、親水性やゼータ電位も大きく変化しており、カルボキシル基は増加しているものと考えられる。生体表面にはカルボキシル基やアミノ基が分布し、生体機能の一部をになっているため、生体と同じく炭素と水素で構成されるDLCに官能基を付加する事でより生体に近づけたDLC、Biomimetic DLCを構想しているが、本研究によりBiomimeticなDLC開発に一歩近づいた。血液適合性は低下したが、抗細菌性が一部確認されており、C-DLC自体の実用化用途もあると判明した。
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