Effect of N typeCCB on development of abdominal aortic aneurysm

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09127
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Okayama University
• Principal Investigator: Uchida Haruhito 岡山大学, 医歯薬学域, 教授 (00550857)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 腹部大動脈瘤 / N型カルシウムチャンネル

Outline of Final Research Achievements

In this study, we focused on the significance of N-type calcium channels (N-type CC) in the development and progression of abdominal aortic aneurysms, and aimed to elucidate their importance and molecular mechanisms. Therefore, we conducted experiments using N-type CC knockout mice (α1B knockout mice), which are gene mutant mice, and experiments using N-type CC antagonists, respectively, and found that both models significantly suppressed the onset and progression of abdominal aortic aneurysms. In vitro experiments, selective inhibition of N-type CC showed a strong inhibitory effect on oxidative stress and inflammation. In conclusion, our study showed that N-type CC is deeply involved in the onset and progression of abdominal aortic aneurysms.

Free Research Field

心臓血管外科

Academic Significance and Societal Importance of the Research Achievements

腹部大動脈瘤はひとたび破裂すると致死的な非常に重篤な疾患である。現在治療は外科的なものに限られている。今回の我々の基礎的な検討によりN型カルシウムチャンネルが腹部大動脈瘤の発症・進展にかかわることが明らかとなった。この結果から、N型カルシウムチャンネルを有効に阻害する新規治療の開発につながる成果と考えられ、これらの新規治療の開発がもたらず人命救助の観点からその社会的意義は大きいと考えられる。