2022 Fiscal Year Final Research Report

Elucidation of molecular mechanism of systemic vascular changes due to aortic stenosis-role of platelet activation by shear stress

Research Project

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Project/Area Number	20K09130
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 55030:Cardiovascular surgery-related
Research Institution	Kagoshima University
Principal Investigator	Kanda Hideaki 鹿児島大学, 医歯学域医学系, 助教 (50598274)
Co-Investigator(Kenkyū-buntansha)	松本和久鹿児島大学, 医歯学域鹿児島大学病院, 助教 (10363631) 山口宗一鹿児島大学, 医歯学域医学系, 准教授 (20325814) 井本浩鹿児島大学, 医歯学域医学系, 教授 (60274461) 橋口照人鹿児島大学, 医歯学域医学系, 教授 (70250917) 大川政士鹿児島大学, 鹿児島大学病院, 医員 (90869322)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	大動脈弁狭窄症 / ずり応力 / 血小板 / 血管内皮増殖因子
Outline of Final Research Achievements	Long-term blood samples from patients with aortic stenosis (AS) were analyzed for platelet-related factors. Vascular endothelial growth factor (VEGF), which is abundant in platelets, was higher in AS patients than before surgery. Among them, VEGF-165, which is a subtype that is particularly abundant in platelets, was higher than before surgery even in the first year. It was suggested that although blood flow improves with aortic valve replacement, the prothetic valve may affect platelets. Since the number of subjects was small and the VEGF of the platelets themselves could not be measured, it was not possible to make a firm statement, it was considered necessary to accumulate cases and further analysis in the future.
Free Research Field	心臓血管外科
Academic Significance and Societal Importance of the Research Achievements	大動脈弁狭窄症および大動脈弁置換術で使用する人工弁が血小板に影響を与えVEGFの推移を起こしている可能性が示唆された。また、大動脈弁狭窄症患者では術前からVEGFの血中濃度が高いことが考えられ、病態の進行に影響を及ぼしている可能性がある。さらには、弁置換術を行った後もVEGF血中濃度が高く、術後患者の状態や移植した人工弁に影響を与えている可能性が考えられた。まだ検討が十分ではないが、本研究と同様に循環器系の他疾患を検討していくことも可能と考えられた。