2022 Fiscal Year Final Research Report

The diversity and specific composition of the oral and gut microbiota in lung cancer patients

Research Project

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Project/Area Number	20K09188
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 55040:Respiratory surgery-related
Research Institution	National Hospital Organization, Kyushu Cancer Center (2021-2022) National Hospital Organization, Kyushu Medical Center (Clinical Institute) (2020)
Principal Investigator	Shoji Fumihiro 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 呼吸器腫瘍科医長 (90444851)
Co-Investigator(Kenkyū-buntansha)	竹尾貞徳独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 統括診療部長 (00416546) 豊川剛二独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 呼吸器外科医師 (30627261) 山崎宏司独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 呼吸器外科科長 (60404068)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	肺癌 / 口腔内細菌叢 / 腸内細菌叢 / 多様性 / 菌種
Outline of Final Research Achievements	This single-center, prospective observational study analyzed both saliva and feces from 74 participants (lung cancer patients: LC, n=53, lung inflammation patients: LI, n=11 and healthy control: HC, n=10). The alpha diversity of the oral microbiota was significantly lower in LC group than in HC group. The beta diversity of both oral and gut microbiota was significantly different among these group. Compositional differences in the oral microbiota were observed between the two groups; c_Bacilli, f_Streptococcaceae, g_Strepotoccus, p_Firmicutes and o_Lactobacillales were more abundant. Significant abundance of total 6 oral-related microbiota were observed in the gut of LC group. Conclusions: This study revealed the oral microbiota in lung cancer patients is significantly different from that in healthy individuals and a significant lower diversity of oral microbiota in lung cancer patients. Specific oral microbiota compositions in lung cancer patients are apparent.
Free Research Field	呼吸器悪性腫瘍
Academic Significance and Societal Importance of the Research Achievements	本研究にて肺癌症例の口腔内細菌叢は多様性が低下しており、また特定の菌種を同定することができた。本研究結果から口腔内細菌叢を利用した肺癌リスク判定や肺癌予防へとつながる可能性が示唆された。