2022 Fiscal Year Final Research Report
Do neurotensin influence the effects of general anesthesia?
| Project/Area Number |
20K09204
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Tohoku Medical and Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉川 雄朗 東北大学, 医学系研究科, 准教授 (70506633)
長沼 史登 東北医科薬科大学, 医学部, 助教 (80780519)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 吸入麻酔薬 / ニューロテンシン |
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| Outline of Final Research Achievements |
We investigated the role of the neurotensinergic nervous system in the loss of consciousness caused by inhaled general anesthetics. Neurotensin was expressed in neurons in the lateral hypothalamus and central amygdala, and projected extensively from the diencephalon to the medulla oblongata. We found that these neurons have the effect of regulating NREM sleep and REM sleep and promoting wakefulness. Using methods of chemgeneics and fiber photometry, we presumed that the activity of neurotensinergic neurons was not associated with the induction or recovery of general anesthesia.
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| Free Research Field |
神経薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
皮質下覚醒系神経回路は、覚醒のみならず認知記憶機能も調節する。本邦では手術麻酔患者が著しく高齢化したため、術後認知機能障害は主要な術後合併症の一つとして喫緊の対策が求められている。今後の研究のさらなる発展によって、ニューロテンシン神経系とその下流の小分子神経伝達物質神経核の吸入麻酔における役割が明らかになれば、皮質下覚醒系神経回路の認知記憶機能における吸入麻酔薬の影響を特異的に解析できるため、術後覚醒遅延や術後認知機能障害の病態解明・治療開発の研究基盤になる可能性があると考える。
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