2023 Fiscal Year Final Research Report
Real-time monitoring of breath volatile organic compounds for early detection of perioperative organ injury
| Project/Area Number |
20K09223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
李 丞祐 北九州市立大学, 国際環境工学部, 教授 (60326460)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 揮発性有機化合物 / アンモニア / 術後臓器障害 / 酸化ストレス / 炎症反応 |
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| Outline of Final Research Achievements |
Urine was collected before and after various surgeries and transferred to a device to extract urinary VOCs, which were comprehensively analyzed by GC-MS. The results revealed that the variable VOCs differed depending on the operated organ. In gastrointestinal surgeries, six VOCs were significantly increased and decreased postoperatively compared to the others, which may be markers of cancer.
Recently, ammonia was successfully measured in real-time in gastrointestinal and renal surgeries using an ammonia measuring device developed by TOYOKO KAGAKU Co. and Professor Lee. In both of these cases, the changes were within the normal range, and no postoperative organ injury resulted. We plan to continue to accumulate more cases in the future.
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| Free Research Field |
麻酔・集中治療
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| Academic Significance and Societal Importance of the Research Achievements |
術前後に変動するVOCsが手術する臓器により異なることが明らかとなったが、VOCsは各種臓器傷害のマーカーとなるだけではなく、疾患や癌のマーカーとなる可能性があることが示唆された。また、揮発性無機ガスのアンモニアは、肝だけでなく、腎機能とも関連する重要なバイオマーカーである。本研究では、新規モジュール化光学センサを用いて、呼気アンモニアを高感度で高選択性に測定することが可能となり、消化器外科手術と腎臓外科手術において、アンモニアのリアルタイム測定に成功した。この方法を用いて、術後に生じる急性腎傷害など合併症を早期に検出できるようになることが期待される。
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