2022 Fiscal Year Final Research Report
The effectiveness of cold platelet for trauma and great vessel surgery
| Project/Area Number |
20K09230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮田 茂樹 国立研究開発法人国立循環器病研究センター, 研究所, 客員研究員 (20239411)
小亀 浩市 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (40270730)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 冷蔵血小板 |
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| Outline of Final Research Achievements |
In this study, we planned and compared two types of experimental systems: (1) comparison of room temperature and refrigerated PC (in vitro), and (2) addition of PC to a blood sample after cardiopulmonary bypass (ex vivo) in a test tube that simulated clinical practice. Study was carried out.
[Results] 21 patients. Room temperature/refrigerated PC average storage period 8.1±3.3 days. In vitro, refrigerated PC showed significantly higher mean platelet volume (MPV) and aggregation ability than ristocetin. Ex-vivo, TEG platelet mapping showed a significant difference between R and arachidonic acid (AA).
[Conclusion] After an average of 8 days of storage, refrigerated PC was superior to room temperature PC in both in vitro and ex vivo platelet functions.
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| Free Research Field |
麻酔科学
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| Academic Significance and Societal Importance of the Research Achievements |
in vitroでは冷蔵PC はMean platelet volume (MPV)とリストセチン以外の凝集能にて有意に高値を示した。ex-vivoではTEG Platelet mappingにてRとアラキドン酸（AA）に有意差が認められた。
平均8日間保存で冷蔵PCは室温PCに比べ、in vitro、ex vivoともに上記血小板機能が優れていた。冷蔵血小板は備蓄ができる可能性があり、外傷へのMTP対応に役立つ可能性がある。
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