Impacts of a local anesthetic infiltration on repair of surgically incised muscles and its analgesic effects

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09239
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Shinshu University
• Principal Investigator: Tanaka Satoshi 信州大学, 医学部, 特任教授 (60293510)
• Co-Investigator(Kenkyū-buntansha): 布施谷 仁志 信州大学, 学術研究院医学系(医学部附属病院), 助教 (00588197) ; 杉山 由紀 信州大学, 学術研究院医学系(医学部附属病院), 講師 (10468100) ; 川真田 樹人 信州大学, 学術研究院医学系, 教授 (90315523)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 局所麻酔薬 / 術後痛

Outline of Final Research Achievements

Single and repeated infiltration of 0.5% ropivacaine in surgically incised abdominal muscles of rats significantly augmented laparotomy-induced muscle injury and increased the numbers of CD68-positve macrophages and MyoD-positive cells compared to those with infiltration of saline or 0.25% ropivacaine. In contrast, there were no significant differences in them between rats with saline infusion and rats with 0.25% ropivacaine infiltration. Pain-related behaviors were inhibited by 0.25% and 0.5% of ropivacaine for 2 h after surgery. In conclusion, single or repeated subfascial infiltration of 0.25% ropivacaine can be used without exacerbating the damage and inflammation in surgically incised muscles, but the use of 0.5% ropivacaine may be a concern because of potentially increased muscle damage.

Free Research Field

局所麻酔薬

Academic Significance and Societal Importance of the Research Achievements

臨床において、鎮痛効果を期待して筋近傍や筋創部に局所麻酔薬が投与されている。局所麻酔薬の筋切開部位への投与は鎮痛効果を有するが、高濃度局所麻酔薬は、筋切開部の損傷・修復に影響を与える可能性がある。本研究の成果は、鎮痛効果と筋組織障害・再生のバランスを考慮した最適な投与濃度を検討するための、重要な資料となる。