2022 Fiscal Year Final Research Report
The role of mitochondrial heteroplasmy in sepsis
Project/Area Number |
20K09293
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 55060:Emergency medicine-related
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Research Institution | Nara Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
趙 晶 奈良県立医科大学, 医学部, 助教 (60804466)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 敗血症 / ミトコンドリア / 炎症 |
Outline of Final Research Achievements |
Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a major public health concern with high mortality and morbidity. In this study we observed that the accumulation of mitochondrial mutation exacerbates the pathogenesis of sepsis by increasing inflammatory responses in vitro and in vivo. We also found that mitochondrial dynamics is implicated in the pathogenesis of sepsis by regulating mitochondrial DNA integrity.
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Free Research Field |
集中治療
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Academic Significance and Societal Importance of the Research Achievements |
今回の研究においてヘテロプラスミーの敗血症における役割及びヘテロプラスミーを制御する因子を解明したことは、敗血症の新たな病態の解明だけに留まらず、新規治療戦略策定にも寄与すると考えられる。さらに、本研究成果は敗血症のみならずmtDNA変異が関与する多くの難治性疾患の新たな治療標的の発見につながる可能性もあり重要性の高いものである。
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