Dietary Phytoestrogen Reduces Intracranial Aneurysm Formation in Ovariectomized Female Mice

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09323
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Hiramatsu Hisaya 浜松医科大学, 医学部, 協定訪問共同研究員 (70447803)
• Co-Investigator(Kenkyū-buntansha): 神尾 佳宣 浜松医科大学, 医学部附属病院, 助教 (10829716)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 植物性エストロゲン / 腸内細菌

Outline of Final Research Achievements

Postmenopausal women have a higher incidence of intracranial aneurysmal rupture than men of the same age. Equol, a phytoestrogen produced by the gut microbiota from dietary daidzein, is known to preferentially bind to estrogen receptor-beta. The aim of study is to verify equol supplement reduces intracranial aneurysm formation in ovariectomized female mice via gut microbiota.
In our experiment, we showed that dietary phytoestrogen significantly reduced intracranial aneurysm formation in ovariectomized female mice. Dietary phytoestrogen with vancomycin had high incidence of aneurysm formation.
Equol produced by the gut microbiota from dietary phytoestrogen may play important role in aneurysm formation.

Free Research Field

脳卒中

Academic Significance and Societal Importance of the Research Achievements

腸内細菌を介して生成された女性ホルモン類似物質は脳動脈瘤形成を抑制した結果から、疫学的に閉経前後の女性に多く発症する脳動脈瘤破裂によるくも膜下出血に関して、女性ホルモンが重要な役割を担っていることが本研究を通して示すことができた。脳動脈瘤形成・破裂の高リスクである閉経前後女性への食事療法および栄養学における予防医学観点から重要であり、新しい治療につながることが期待される。