2023 Fiscal Year Final Research Report

Brain Plasticity in Functional Recovery Following Stem Cell Transplantation for Stroke

Research Project

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Project/Area Number	20K09328
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56010:Neurosurgery-related
Research Institution	Nagasaki University
Principal Investigator	Hiu Takeshi 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (00404260)
Co-Investigator(Kenkyū-buntansha)	伊木勇輔長崎大学, 病院(医学系), 医員 (00772154) 定方英作長崎大学, 病院(医学系), 助手 (10772139) 堀江信貴広島大学, 医系科学研究科(医), 教授 (70380912) 松尾孝之長崎大学, 医歯薬学総合研究科(医学系), 教授 (00274655) 馬場史郎長崎大学, 病院(医学系), 講師 (30530430) 氏福健太長崎大学, 医歯薬学総合研究科(医学系), 助教 (20437867) 平山航輔長崎大学, 病院(医学系), 医員 (00896326)
Project Period (FY)	2020-04-01 – 2024-03-31
Keywords	Stem cell / Stroke
Outline of Final Research Achievements	Stem cell therapy for ischemic stroke holds promise, particularly intraarterial (IA) transplantation. During the acute to subacute phases, stem cell transplantation promotes angiogenesis. In the infarct core (IC), within 24 hours post-stroke, neurons, astrocytes, and microglia secrete VEGF, peaking on day 3. In the periinfarct area (PI), pericytes secrete VEGF, aiding endothelial cell (EC) proliferation. In the subacute phase, VEGF and PDGF-BB enhance mature angiogenesis. In acute phase IA stem cell transplantation, stem cells are widely distributed in the IC and PI, while in the subacute phase, they are mainly in the PI. Transplanted stem cells secrete various growth factors, including VEGF and PDGF-BB, promoting angiogenesis and reducing infarct volume. IA transplantation has shown safety but improving efficacy requires enhanced migration and long-term survival of transplanted cells. Further research is needed to achieve these advancements.
Free Research Field	脳神経外科
Academic Significance and Societal Importance of the Research Achievements	虚血性脳卒中に対する幹細胞療法は、神経障害の治療に期待が寄せられており、初期の臨床試験が進行中である。急性期から亜急性期にかけて、幹細胞移植は血管新生を促進する。亜急性期には、VEGFとPDGF-BBが成熟した血管新生を促進する。動脈内移植は安全性が確認されているが、有効性向上には移植細胞の移動促進と長期生存する細胞の開発が必要であり、さらなる研究が期待される。