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2022 Fiscal Year Final Research Report

Development of novel therapeutic method for unstable carotid plaque focusing on neutrophil extracellular traps

Research Project

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Project/Area Number 20K09342
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionUniversity of Toyama

Principal Investigator

KASHIWAZAKI Daina  富山大学, 学術研究部医学系, 講師 (50374484)

Co-Investigator(Kenkyū-buntansha) 黒田 敏  富山大学, 学術研究部医学系, 教授 (10301904)
桑山 直也  富山大学, 学術研究部医学系, 准教授 (30178157)
秋岡 直樹  富山大学, 学術研究部医学系, 講師 (70422631)
Project Period (FY) 2020-04-01 – 2023-03-31
KeywordsCarotid plaque / 好中球細胞外トラップ / 拡張血管 / unstable plaque / calcification
Outline of Final Research Achievements

NETs was presented in unstable plaque in histological specimen. There were significant difference between unstable and stable plaque(P<0.01) Our study suggested NETs play a crucial role of development of unstable plaque in carotid stenosis.

Free Research Field

脳神経外科学

Academic Significance and Societal Importance of the Research Achievements

内頚動脈狭窄症の不安定プラークの発症機序をNETsの観点から解明した。今後の不安定プラークの創薬の一助になると考えられる。

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Published: 2024-01-30  

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