Gamma oscillation regularity quantification and dynamic analysis for epileptic lesion and network depiction.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09356
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Showa University
• Principal Investigator: Sato Yosuke 昭和大学, 医学部, 講師 (70594349)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: てんかん / ガンマ波規則性 / 脳神経外科

Outline of Final Research Achievements

Gamma oscillation regularity analysis using intraoperative brain surface EEG data in neurosurgery for cerebral cavernous angiomas was shown to be effective in the assessment of epileptic lesion areas (J Neurosurg Case Lessons. 2021). Gamma oscillation regularity correlation analysis using brain surface EEG data was also shown to be effective in the assessment of epileptic networks (Surg Neurol Int. 2021, 2022). Furthermore, gamma oscillation regularity analysis using scalp EEG data in epilepsy surgery with various brain lesions was shown to be effective as a preoperative assessment of epileptic lesions (Oper Neurosurg. 2022).

Free Research Field

脳神経外科

Academic Significance and Societal Importance of the Research Achievements

本研究におけるガンマ波規則性解析は、発作の有無に関わらず安静時の背景活動脳波からてんかん病変部が評価可能であり、一般的脳波計でも評価可能である。本研究成果は安全で確実な低侵襲てんかん外科治療の実現に結びつき、てんかん患者の機能予後改善に寄与できる重要度の高いものである。