Development of a technique to improve the accuracy of noninvasive cerebral perfusion measurement by arterial spin-labeling method using vascular signal suppression.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09397
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Iwate Medical University
• Principal Investigator: Matsuda Tsuyoshi 岩手医科大学, 医歯薬総合研究所, 助教 (70501641)
• Co-Investigator(Kenkyū-buntansha): 小笠原 邦昭 岩手医科大学, 医学部, 教授 (00305989) ; 佐々木 真理 岩手医科大学, 医歯薬総合研究所, 教授 (80205864) ; 上野 育子 岩手医科大学, 医歯薬総合研究所, 講師 (20468317)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 多時相ASL / CBF計測 / CBV計測 / MTT計測 / 脳虚血

Outline of Final Research Achievements

By using the DANTE method just before imaging sequence of the multi-PLD ASL method, intravascular signal-suppressed ASL images with a high signal-to-noise ratio were obtained. Using the volunteer images, we confirmed that the DANTE method can produce the higher signal-to-noise ratio images than the MSDE method.
We proposed an equation of the ASL signal when CBV was change and developed the ASL analysis software. Significant differences in LTT, CBF, and CBV with and without the DANTE method in the healthy volunteer images were confirmed. On the patients with hemodynamic cerebral ischemia, LTT, CBV and MTT showed significant correlation with SPECT CVR. These results indicate that it is possible to develop ASL analysis software by using DANTE multi PLD ASL images that reflects clinical conditions, and to evaluate cerebral hemodynamics noninvasively.

Free Research Field

医科学

Academic Significance and Societal Importance of the Research Achievements

多時相ASL法で得られた画像を考案した手法で解析することで、画像診断で用いられる血流動態の評価パラメータであるCBFのみならずCBVとMTTを、血行力学的脳虚血患者で得られる可能性があることを明らかにした。多時相ASLの画像は普及率の高いMRI装置を使用して造影剤などの薬剤投与なしで得られるために、被曝や薬剤による副作用、コストは生じない。従って繰り返し検査やフォトーアップが必用な血行力学的脳虚血患者に対する社会的意義は高いと考えられる。