2022 Fiscal Year Final Research Report
Administration of the GLP-1 receptor agonist enhances the ER stress response and improves functional recovery in the secondary injury process after spinal cord injury
| Project/Area Number |
20K09417
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
加藤 裕幸 東海大学, 医学部, 准教授 (40348678)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 脊髄損傷 / 脊髄損傷２次障害 / 小胞体ストレス応答 / アポトーシス / GLP-1受容体作動薬 |
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| Outline of Final Research Achievements |
Apoptosis is a key factor in the secondary injury process after spinal cord injury that aggravates the damage to the injured spinal cord, and endoplasmic reticulum stress is one of the main apoptosis pathways in the central nervous system. GLP-1 receptor agonist, which enhances the ER stress response, decreased the area of lesion and improved the function after spinal cord injury. GLP-1 receptor agonist also brought about the positive effect in M1/M2 rate of macrophage and the blood spinal cord barrier, showing great potential for the treatment of SCI.
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| Free Research Field |
整形外科学
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| Academic Significance and Societal Importance of the Research Achievements |
外傷性脊髄損傷における障害は二次障害により拡大するが、その主体をなすのがアポトーシスであり、中枢神経では小胞体ストレスが重要な経路である．二次障害は損傷の拡大に加えて、再生のために誘導・増殖されたオリゴデンドロサイト前駆細胞の生存分化も障害し、再髄鞘形成を阻害する．すなわち損傷脊髄内でのグリア細胞のアポトーシス抑制が可能であれば、二次障害による損傷範囲拡大の軽減、再髄鞘形成による脊髄損傷後の麻痺の軽減へとつながる可能性がある．小胞体ストレス応答能増強効果が報告されているGLP-1受容体作動薬の効果を検討し良好な結果を得た．今後の臨床応用を目指したい．
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