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2022 Fiscal Year Final Research Report

The role of adipocyte-derived hormones/extracellular vesicles on bone-metastasized cancer

Research Project

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Project/Area Number 20K09422
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionKanagawa Cancer Center Research Institute

Principal Investigator

Sato Shinya  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所, 医長・室長 (30464564)

Co-Investigator(Kenkyū-buntansha) 比留間 徹  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 部長 (20254188)
星野 大輔  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 部長代理 (30571434)
鷲見 公太  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 医師 (30716733)
Project Period (FY) 2020-04-01 – 2023-03-31
Keywordsadipo-oncology / 腫瘍関連脂肪細胞 / がん微小環境 / 骨転移 / 治療抵抗性 / 腫瘍免疫 / AI解析 / 骨髄脂肪細胞
Outline of Final Research Achievements

In this study, we conducted a fundamental study to determine the role of adipocytes in cancer progression in bone metastases. First, AI analysis of pathology images containing cancer and adipose tissue showed that adipocytes-containing tissues are important for the presence of cancer. Next, histopathological analysis of 144 patients with bone metastases was performed. The results showed that in the invasive fronts of bone metastases, the presence of bone marrow adipocytes increased the density of cancer-associated fibroblasts and decreased the density of CD8-positive lymphocytes. Cancer metastasized to the adipocyte-rich marrow had increased expression of genes related to tumor immune evasion and drug treatment resistance compared to the primary cancer. These results are reported in the papers. To obtain MOA for these findings, we established cell and animal experimental systems for investigating the role of adipocyte secretion factors in cancer.

Free Research Field

腫瘍病理学

Academic Significance and Societal Importance of the Research Achievements

本研究において、骨転移巣において脂肪細胞が局所における癌の進展に寄与する可能性を示すことができた。また、そのメカニズムとして腫瘍免疫回避、腫瘍関連線維芽細胞の誘導が起きている可能性が示唆された。本研究結果は、脂肪細胞およびその分泌因子をがんの治療標的として認識する必要性を明らかにした点で学術的意義・社会的意義がある。

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Published: 2024-01-30  

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