2022 Fiscal Year Final Research Report

The protective effects of new mitochondrial modulators on onset and progression of osteoarthritis

Research Project

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Project/Area Number	20K09426
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56020:Orthopedics-related
Research Institution	Tohoku University
Principal Investigator	Hashimoto Ko 東北大学, 医学系研究科, 講師 (00718497)
Co-Investigator(Kenkyū-buntansha)	鈴木健弘東北大学, 医工学研究科, 特任准教授 (50396438) 阿部高明東北大学, 医工学研究科, 教授 (80292209)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	ミトコンドリア代謝改善薬 / 変形性関節症
Outline of Final Research Achievements	We conducted various experiments to investigate the effect of MA-5, a novel compound that improves mitochondrial function, on the onset and progression of osteoarthritis (OA). Specifically, we created a mouse model of ”Destbilization of medial meniscus" (DMM) that induces OA in the knee joint, administered MA-5 orally daily for 4-8 weeks, and examined whether changes in the degree and morphology of knee OA occurred compared to the control group. The results showed a slight attenuation of cartilage degeneration in the MA-5-treated group compared to the non-treated group. This is an important finding that MA-5 has some protective effect on OA changes in knee cartilage.
Free Research Field	脊椎外科、関節軟骨・筋の分子生物学
Academic Significance and Societal Importance of the Research Achievements	本研究は、新規ミトコンドリア代謝改善薬MA-5が関節軟骨損傷に対して抑制的に働くことを示した世界初の研究である。現時点では変形性関節症に対して経口投与により優位に関節軟骨破壊を抑制する薬剤はない。本研究の成果は、今後の変形性関節症の傾向治療薬の開発に向けた新規ミトコンドリア機能改善役の嚆矢であり、今後の研究発展により人類の多くが関節症による痛みから開放される可能を秘めている点に置いて、社会的意義が大きい。