Osteoimmunology network between innate immunity and osteoclast

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09429
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: The University of Tokyo
• Principal Investigator: Omata Yasunori 東京大学, 医学部附属病院, 特任准教授 (40570734)
• Co-Investigator(Kenkyū-buntansha): 矢野 文子 東京大学, 医学部附属病院, 届出研究員 (80529040)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 自然免疫細胞 / 破骨細胞

Outline of Final Research Achievements

While the role of T cells in the regulation of bone homeostasis is well defined, little is known about the role of innate lymphoid cells (ILCs) on bone. ILCs are innate immune cells that share cytokine expression patterns with T cells but lack the T cell receptor. In this study we show that type 2 ILCs (ILC2) potently inhibit the generation of bone resorbing osteoclasts in vitro as well as favorably influence bone homeostasis under steady state conditions in vivo using loss and gain of function models. Furthermore, adoptive transfer of ILC2 completely abrogated ovariectomy-induced bone loss by significantly down-regulating osteoclast numbers in vivo.

Free Research Field

分子細胞生物学

Academic Significance and Societal Importance of the Research Achievements

In this study we show that type 2 ILCs (ILC2) potently inhibit the generation of bone resorbing osteoclasts in vitro as well as favorably influence bone homeostasis under steady state conditions in vivo using loss and gain of function models. The new insight will uncover the bone and immune biology.