The mechanism of anti-inflammatory effect for inflammatory arthritis by spheroid-type adipose-derived stem cells

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09486
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Osaka Metropolitan University (2022); Osaka City University (2020-2021)
• Principal Investigator: Okano Tadashi 大阪公立大学, 大学院医学研究科, 病院講師 (50754826)
• Co-Investigator(Kenkyū-buntansha): 折田 久美 大阪公立大学, 大学院医学研究科, 博士研究員 (40748597)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 脂肪由来幹細胞 / 関節リウマチ / 抗炎症作用 / 組織修復 / 関節炎

Outline of Final Research Achievements

Adipose-derived stem cells are stem cells separated and cultured from allogeneic adipocytes, and are reported to have anti-inflammatory effects and tissue repair ability. In order to suppress irreversible joint destruction in chronic arthritic diseases such as rheumatoid arthritis, recent treatment with systemic administration of biologics targeting specific inflammatory cytokines has been performed, but there are side effects and complications. There are many patients who cannot use from these points of view, it is important to find a useful method that can relatively safely obtain a high inhibitory effect on arthritis by local administration in clinical practice.
In this study, we focused on the anti-inflammatory effects of adipose-derived stem cells, and confirmed that spheroids shape of adipose-derived stem cells are the most effective form in arthritis models.

Free Research Field

関節炎

Academic Significance and Societal Importance of the Research Achievements

我々は関節局所へ脂肪由来幹細胞をある程度の期間留置させる事が重要と考え、細胞塊であるスフェロイドを使用することでその有効性がさらに高まる可能性について検証した。脂肪由来幹細胞は細胞レベルでも抗炎症効果があるが、スフェロイド型にすることでより抗炎症作用が確認された。今後、関節リウマチなどの関節炎に対する新たな臨床応用に繋げ、患者のQOL向上に貢献できる可能性があると考えられた。