Evaluation of the mechanism and development of inhibitory methods of muscular fatty infiltration after rotator cuff tears

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K09488
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Keio University
• Principal Investigator: Matsumura Noboru 慶應義塾大学, 医学部(信濃町), 講師 (70383859)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 筋変性 / 腱板断裂 / 腱板構成筋 / 脂肪浸潤 / 線維化 / 加齢

Outline of Final Research Achievements

Muscle degeneration with fatty infiltration and muscle atrophy can be caused by aging and trauma, but the mechanism remains unclear. In particular, the shoulder rotator cuff has the highest rate of tendon rupture in the human body, and chronic rotator cuff tears are known to be associated with muscle degeneration.
Muscle fatty infiltration of rotator cuff component muscles is considered an irreversible change after rotator cuff tear, and elucidation of its mechanism and suppression is a clinically important issue. In this study, we evaluated images of animal models and clinical cases in detail to elucidate the mechanism of degeneration after rotator cuff tear. We also clarified the inhibitory effect of drugs on muscle degeneration.

Free Research Field

整形外科学

Academic Significance and Societal Importance of the Research Achievements

肩腱板は人体の中でも腱断裂の発生頻度が高い部位であり、慢性的な腱板断裂においては筋変性を合併することが知られている。特にPDGFRα陽性間葉系前駆細胞が起源とされる腱板構成筋の筋内脂肪浸潤は腱板断裂後の不可逆的な変化とされており、その予防および抑制が臨床的に重要な課題となる。本研究の目標は、腱板断裂後の筋変性機序を解明し、その抑制・予防法を確立することであった。本研究の一連の成果により筋変性の抑制が可能になれば、良好な筋状態を保つことにより肩腱板断裂に対する治療成績が向上し、また高齢者において問題となるサルコペニアなどの筋変性予防にも繋がっていくことが期待できる。