2023 Fiscal Year Final Research Report
The effects of icing on tissue oxygen tension in the acute phase and the effects of hyperbaric oxygen on regeneration in the injured soft tissue.
| Project/Area Number |
20K09496
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 56020:Orthopedics-related
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
大原 敏之 東京医科歯科大学, 東京医科歯科大学病院, 非常勤講師 (00793001)
小柳津 卓哉 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (60647709)
山本 尚輝 東京医科歯科大学, 医学部附属病院, 特任助教 (60808046)
星野 傑 東京医科歯科大学, 東京医科歯科大学病院, 助教 (70836923)
塩田 幹夫 東京医科歯科大学, 医学部附属病院, 特任助教 (80817635)
|
|---|
| Project Period (FY) |
2020-04-01 – 2024-03-31
|
| Keywords | 骨格筋 / 筋再生 / 高気圧酸素治療 / 圧挫損傷 / アイシング / 温熱 / 酸素濃度 |
|---|
| Outline of Final Research Achievements |
This study used a rat skeletal muscle injury model to assess the effects of icing and heat therapy on tissue oxygenation and regenerative processes in injured skeletal muscle, and to examine the effectiveness of a hyperbaric oxygen (HBO) environment combined with icing. Results showed that oxygen tension was significantly decreased by icing and significantly increased by heat therapy and HBO compared to the control group at 30 minutes after injury. Tissue oxygen tension was restored to a normal level more quickly when icing was combined with HBO. The number of regenerating muscle fibers was significantly increased by hyperthermia, HBO, and HBO combined with icing at 5 days after injury. Icing during the acute phase of injury leads hypoxic environment in skeletal muscle, but the combination of icing and HBO may improve the hypoxic environment and promote skeletal muscle regeneration. Heat therapy suppressed the decrease of oxygen tension and was observed to promote muscle regeneration.
|
| Free Research Field |
高気圧酸素医学
|
| Academic Significance and Societal Importance of the Research Achievements |
外傷急性期の処置として考えられているRICE療法もしくはPRICE療法の中でもアイシングについては、組織酸素化もしくは組織修復への影響についてはエビデンスが少なかった、今回の研究結果で、少なくとも組織酸素濃度の観点からは漫然としたアイシングには注意が必要なことを、スポーツ現場に警鐘を鳴らすことができるだろう。また酸素や高気圧酸素の併用によりアイシングの悪影響を最小限にする可能性を示すこととなり、酸素や高気圧酸素が新たな急性期処置として期待される。
|
