2022 Fiscal Year Final Research Report
the study of new treatment for spinal metastasis with the combination of sustained release anti-cancer drug and non-metal spinal instrumentation
| Project/Area Number |
20K09505
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
豊田 紀章 兵庫県立大学, 工学研究科, 教授 (00382276)
張 鍾穎 神戸大学, 医学研究科, 医学研究員 (00824195)
由留部 崇 神戸大学, 医学部附属病院, 助教 (10514648)
垣内 裕司 神戸大学, 医学部附属病院, 医員 (40849212)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 脊椎転移 / 徐放化抗癌剤 / 非金属脊椎インプラント |
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| Outline of Final Research Achievements |
Experiments were conducted to prepare sustained-release anticancer drugs and to confirm the effects of sustained-release anticancer drugs using rat bone metastasis models. A sustained-release anticancer drug was locally administered to bone metastasis model rats and evaluated over time.
The sustained-release anticancer drug showed a higher antitumor effect than the systemic administration group, while reducing side effects such as weight loss and renal dysfunction.
In addition, in research and development of non-metallic spinal implants, strength tests of implants were conducted using the finite element method. Experiments on the radiation artifact of the PEEK screw are in the preliminary stage.
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| Free Research Field |
脊椎外科
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| Academic Significance and Societal Importance of the Research Achievements |
担がん患者は増え続ける一方であり、同時に脊椎転移により疼痛や麻痺症状のため、休職や退職を余儀なくされるケースが増えている。脊椎転移に対する新しい治療戦略は、単に担がん患者の治療だけではなく、少子高齢化を歩み続ける日本において労働人工の維持・向上に寄与するものと考える。
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