Development of novel urethral catheter for the transurethral treatment of urethral stenosis

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K09534
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56030:Urology-related
• Research Institution: National Defense Medical College
• Principal Investigator: Horiguchi Akio 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 泌尿器科, 准教授 (20286553)
• Co-Investigator(Kenkyū-buntansha): 櫛引 俊宏 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 医用工学, 准教授 (30403158) ; 東 隆一 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 形成外科, 教授 (00531112)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 難治性尿道狭窄症 / バイオマテリアル / 再狭窄予防

Outline of Final Research Achievements

We demonstrated the possibility of preventing restenosis after transurethral treatment of urethral stricture by using a newly developed photocrosslinked wound dressing.
The rabbit urethral stricture model used in this study was highly reproducible and could be observed over a long period of time, and we believe that the model mimicked the course of treatment of human urethral stricture. The newly developed photocrosslinked wound dressing gelated with sufficient strength after a short period of visible light irradiation, and could be fitted to an irregular wound surface after urethral dilatation. The use of the photocrosslinked wound dressing prevents restenosis after transurethral urethral treatment of severe urethral stricture that affects the penile corpus cavernosum, for which transurethral treatment is not originally indicated.

Free Research Field

尿道狭窄症

Academic Significance and Societal Importance of the Research Achievements

尿道狭窄症治療後の再狭窄予防には、尿道組織の再瘢痕化が進む前に上皮組織再生を促進させ、尿道粘膜下組織の再構築を正常に誘導することが必要である。本研究で新しく開発した尿道再狭窄を予防する方法は、尿道狭窄症治療患者の再狭窄予防率を高め、予後の利益に資すると考えられる。