2022 Fiscal Year Final Research Report
Analysis of enhancement of endometrial implantation potential and ovarian protection by tamoxifen in breast cancer patients
Project/Area Number |
20K09664
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
石川 聡子 金沢大学, 附属病院, 助教 (10815723)
藤原 浩 金沢大学, 医学系, 教授 (30252456)
大黒 多希子 金沢大学, 疾患モデル総合研究センター, 教授 (30767249)
井口 雅史 金沢医科大学, 大学病院, 准教授 (90401918)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | tamoxifen / fertility / breast cancer treatment |
Outline of Final Research Achievements |
We investigated the effect of breast cancer treatment (chemotherapy, hormone therapy) on fertility at breast cancer treatment facilities and reproductive medical facilities nationwide, and reported the results in a paper. Responses were received from 312 breast cancer treatment facilities and 542 reproductive facilities. It was published as an invited article in JOGR magazine. (Yamazaki R et al. 2020 Oct 15. ) In addition, we narrowed down the facilities and retrospectively investigated in detail the effects of breast cancer treatment on pregnancy. We examined the factors affecting pregnancy, reported to the Japanese Society of Obstetrics and Gynecology in April 2021, and published it in JOGR. (December 7 2021)
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Free Research Field |
reproduction
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Academic Significance and Societal Importance of the Research Achievements |
乳癌治療(化学療法、ホルモン療法)の妊孕性に与える影響について全国の乳癌治療施設、生殖医療施設にアンケート調査を行い、実態調査をした。(Yamazaki R etal. J Obstet Gynaecol Res. 2020 Oct 15.)また、施設を絞って後方視的に乳癌治療別に妊娠へ与える影響について詳細に調査した(Yamazaki R,J Obstet Gynaecol Res. December 7 2021.)化学療法後、妊娠する症例は3ヶ月以内に集中していることやタモキシフェンが、若年ではむしろ妊娠率向上に関わる可能性があるなど、乳癌患者の妊娠を目指す際の指標が提示できた。
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