2022 Fiscal Year Final Research Report
Role of NADPH oxidase in eosinophilic sinusitis
| Project/Area Number |
20K09690
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 好酸球性副鼻腔炎 / NADPHオキシダーゼ / DUOX1 |
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| Outline of Final Research Achievements |
The mechanism of DUOX1 involved in epithelium-derived cytokine production was investigated. Stimulation of epithelial cells with mite antigen or ATP induced DUOX1 rapidly. DUOX1 expression increased in a concentration-dependent manner. TSLP and IL-25 production by antigen stimulation also correlated with the induction of DUOX1. Expression of DUOX1 in nasal epithelial cells in eosinophilic sinusitis was decreased, whereas tick antigen stimulation induced an increase in DUOX1 at the protein and mRNA levels. Stimulation (damage) of epithelial cells by antigen resulted in induction of epithelium-derived cytokines via DUOX1. This may have an effect on the pathogenesis of eosinophilic sinusitis.
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| Free Research Field |
耳鼻咽喉科・頭頸部外科
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| Academic Significance and Societal Importance of the Research Achievements |
DUOX1が好酸球性副鼻腔炎の悪化に関与していることが分かった。これにより、環境ストレスが病態の悪化に寄与していることが想定され、新たな治療開発につながる可能性を見出した。
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