Basic research of SIRT1 activator to treat eosinophilic sinusitis

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K09703
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Hokkaido University
• Principal Investigator: Nakamaru Yuji 北海道大学, 医学研究院, 准教授 (20344509)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 好酸球性副鼻腔炎 / SIRT1 / サーチュイン

Outline of Final Research Achievements

To investigate the role of SIRT1 in the pathology of eosinophilic sinusitis, we evaluated 1. SIRT1 expression in the inflamed area of eosinophilic sinusitis, and 2. SIRT1-induced changes in nasal mucosal epithelial barrier function. First, the expression of SIRT1 in the inflamed area of eosinophilic sinusitis was confirmed by immunohistochemical staining. SIRT1 expression in the inferior turbinate mucosa was found to be abundant in epithelial cells. Next, to examine epithelial barrier function, we investigated the role of SIRT1 in the transepithelial barrier function of the nasal mucosal epithelium. No change in barrier function was observed with the use of inhibitors and promoter drug alone.

Free Research Field

アレルギー

Academic Significance and Societal Importance of the Research Achievements

好酸球性副鼻腔炎は中高年で発症するが、鼻粘膜は生下時から感染やストレスにさらされているにもかかわらず、なぜ中高年で発症するのか不明であった。本研究では老化の保護因子であるSIRT1蛋白に注目し、好酸球性副鼻腔炎鼻粘膜上皮バリア機能障害におけるSIRT1の関与を調べる。SIRT1が関与することが証明されば、好酸球性副鼻腔炎の病態において最も重要な発症の引き金が解明される。