Genetic alterations and expressions of immune check point molecules in sinonasal neuroendocrine carcinoma

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09731
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Kobe University
• Principal Investigator: Kiyota Naomi 神戸大学, 医学部附属病院, 特命准教授 (40515037)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 鼻副鼻腔神経内分泌腫瘍 / 嗅神経芽細胞腫 / 次世代シーケンサー / 腫瘍免疫微小環境 / 腫瘍遺伝子変異量

Outline of Final Research Achievements

Olfactory neuroblastoma is one of the rare head and neck malignancies. There have been scarce data about genetic variant, tumor mutational burden (TMB) and tumor immune microenvironment (TIME) of ONB. This research elucidated genetic variants and frequency of TMB-High by Oncomine tumor mutational load assay and also explored the TIME of ONB by multiplex fluorescent immunohistochemistry.

Free Research Field

腫瘍内科

Academic Significance and Societal Importance of the Research Achievements

ONBは希少がんであり小さな研究成果の蓄積が病態の解明や治療法の開発につながる。このため、本研究結果から免疫チェックポイント阻害薬を始めとするがん免疫療法の臨床応用の可能性について新たな知見が得られたことは学術的にも社会的にも意義がある。