2023 Fiscal Year Final Research Report
Role of TET family molecules in the efficacy of sublingual immunotherapy and development of novel adjuvant
| Project/Area Number |
20K09736
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 舌下免疫療法 / アレルギー性鼻炎 / TET |
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| Outline of Final Research Achievements |
Sublingual immunotherapy is a curative treatment for allergic rhinitis. We sought to determine the expression of TET family molelcutes and their clinical characteriation in sublingual immunotherapy. Peripheral blood mononuclear cells were collected from patients with Japanese cedar/cypress pollinosis underwent sublingual immunotherapy, and regulatory T cells were separated using magnetic beads. Expressions of TET1, TET2 and TET3 mRNA on regulatory T cells were determined by real-time PCR. Expressions of TET1, TET2 orTET3 mRNA on regulatory T cells were not differenct between before and one year alter sublingual immunotherapy.
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| Free Research Field |
耳鼻咽喉科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究からは、舌下免疫療法における制御性T細胞に発現するTET遺伝子について明確な臨床的な意義は見いだせなかった。
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