Collection of experimental and clinical evidences for relationship between tonsillar focal diseases and palatine tonsil

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09745
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Asahikawa Medical College
• Principal Investigator: Takahara Miki 旭川医科大学, 医学部, 講師 (50322904)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 扁桃病巣疾患 / 掌蹠膿疱症 / IgA腎症 / 胸肋鎖骨過形成症

Outline of Final Research Achievements

Palmoplantar pustulosis(PPP) and IgA nephropathy (IgAN)are known as typical tonsillar focal diseases, and tonsillectomy has been reported to be effective for improvement of the symptoms and findings. Unfortunately, this disease concept was not widely known. We try to establish experimental and clinical evidence for a link between tonsillar focal diseases and palatine tonsil, and enlighten other doctors on the concept. In this serious of studies, we established and published guidance of clinical management for patients with tonsillar focal disease. Moreover, we found that APRIL (a proliferation-inducing ligand) was involved in hyper-production of IgA from the IgAN patients tonsils, and that chemokine receptor CXCR3 was related to homing of tonsillar T-cells to the lesions of glomerulus.

Free Research Field

扁桃病巣疾患

Academic Significance and Societal Importance of the Research Achievements

扁桃病巣疾患診療の手引きが作成されたことで、各関連科の医師にも本疾患における扁桃摘出術の有効性が示され、適応患者の耳鼻咽喉科への紹介が多くなり、扁桃摘出術の恩恵を得る患者が増える可能性が示された。また、扁桃と病巣疾患を結びつける基礎的エビデンスが更に肉づけされたことで、本疾患における病態の理解だけにとどまらず、類似の臨床的側面を持つ自己炎症性疾患や炎症性腸疾患の病態にも肉薄できる可能性が示唆された。