2022 Fiscal Year Final Research Report
Investigation of Biological Reactions around Silicon Breast Implant and etiology of Long-Term Capsule Contraction
| Project/Area Number |
20K09845
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 被膜拘縮 / シリコンブレストインプラント / synovial dysplasia / BIA-ALCL / 線維化 / バイオフィルム / 慢性炎症 / テクスチャードタイプ |
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| Outline of Final Research Achievements |
To clarify the causal relationship between the histological and molecular histological characteristics of the fibrous capsule (hereafter referred to as "capsule"), which is formed on the surface of the prosthesis used in breast plastic surgery, and the patient background and clinical course, and to clarify what exactly is the cause of long-term capsular contracture. Research plan: Protein extraction and various cytokine measurements and analyses of pericapsular tissues were performed from stored specimens of the same patients with defined clinical information from past cases that met the eligibility criteria for this study. Among the information obtained, we investigated the causal relationship between the specified factors (patient background, clinical findings, and postoperative course), cytokine concentrations, and capsular contracture.
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| Free Research Field |
形成再建外科学
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| Academic Significance and Societal Importance of the Research Achievements |
すべての線維化病態に共通するイベントとして、何らかの原因により組織修復過程で異常が生じて線維芽細胞の活性化が持続するため慢性炎症となり組織障害が持続して線維化が生じるとされている。異物を生体内に留置することにより線維化を起こすことは免れないが、背景因子、環境因子、さらに生体内での炎症反応や線維化を起こす過程でのあらゆるバイオマーカー等のデータを蓄積することで、カプセル拘縮あるいはBIA-ALCLの病態解明の糸口となりうる可能性があり、また将来的にカプセル形成の予防法や治療法が開発された際にその有効性を示す指標となりうる。
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