Functional analysis of basement membrane collagen in skin wound healing and basic research for therapeutic application

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K09867
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Okayama University
• Principal Investigator: Yonezawa Tomoko 岡山大学, 医歯薬学域, 助教 (30304299)
• Co-Investigator(Kenkyū-buntansha): 百田 龍輔 岡山大学, 医歯薬学域, 助教 (80263557) ; 稲川 喜一 川崎医科大学, 医学部, 教授 (90268615)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 皮膚 / 創傷治癒 / 細胞外マトリックス

Outline of Final Research Achievements

Our previous studies have shown that type XVIII collagen appears in the regenerative epithelium during the early phase of skin wound healing. In this study, we analyzed temporal changes in the wound healing process using type XVIII collagen knockout mouse and found that the phenotype of knockout mice was different from that of the wild type. Further histological analysis suggested the importance of type XVIII collagen in skin wound healing. Finally, preliminary findings on molecular mechanisms have been obtained, but more detailed studies are needed.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

皮膚は人体最大の臓器であり、外界からの最初のバリアである。皮膚の障害は熱傷、外傷、褥瘡、糖尿病性潰瘍など多岐に渡る。皮膚の創傷治癒において、細胞外マトリックスの関与は大きいとされている。再上皮化における基底膜の再形成や、創収縮における結合組織成分の働きに関する新しい知見は、難治性の治癒を促進するような効果的な治療の開発に役立つと考えられる。