2022 Fiscal Year Final Research Report
Central and peripheral pathology associated with taste impairments in Parkinson's disease model mice
| Project/Area Number |
20K09877
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57010:Oral biological science-related
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| Research Institution | Meikai University |
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Principal Investigator |
SATO Hajime 明海大学, 歯学部, 講師 (10432452)
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| Co-Investigator(Kenkyū-buntansha) |
野崎 一徳 大阪大学, 歯学部附属病院, 准教授 (40379110)
三浦 治郎 大阪大学, 歯学部附属病院, 助教 (70437383)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 味覚障害 / 嗅覚障害 / パーキンソン病 / 冷温度感覚 / メントール |
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| Outline of Final Research Achievements |
Parkinson’s disease (PD) is a neurodegenerative disorder characterized primarily by motor symptoms. However, PD can also cause prodromal non-motor symptoms including sensory dysfunction. It has been recognized that taste impairment also occurs in early to middle stage patients (Oppo et al., 2020; Melis et al., 2021). However, the mechanisms underlying PD-related taste impairment remain unknown. Our study is the first to investigate taste impairment in a presumed animal model in the early-stage of PD (J Parkinson’s Dis, 2022). Interestingly, in our model, the bitter taste and the olfactory impairments occurred simultaneously but they were induced by the catecholamine neurodegeneration in each first relay area (e.g., bitter: NTS and olfactory: OB). On the other hand, temperature sensitivity, cool/cold, also reduces in the PD model mice. Notably, our results shed some light on the importance of conducting future investigations to clarify the complicated PD-related sensory impairments.
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| Free Research Field |
神経生理学
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| Academic Significance and Societal Importance of the Research Achievements |
味覚は、食物摂取を選別するという生存にとってきわめて重要な機能であるだけでなく、「美味しさを味わう」ことを可能にする感覚の一つである。そのため、味覚障害は私たちのQuality of lifeを大きく低下させる。近年、パーキンソン病 (PD)の前駆症状としての味覚障害が注目されているが、その病態は不明であった。本研究成果は、複雑な味覚障害の病態解明の一助となり、新規治療法/治療薬の開発に大きく寄与でき、その学術的/臨床的意義はきわめて高い。また、国民の味覚障害に対する意識を高め、味覚障害から様々な全身疾患の早期発見および早期治療に繋がり、本研究の社会的意義も高い。
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