2022 Fiscal Year Final Research Report
Elucidation of the function of STOX2, a novel oral cancer-specific gene, and its application to diagnosis and treatment
Project/Area Number |
20K09912
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 57020:Oral pathobiological science-related
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Research Institution | Kagoshima University (2021-2022) Nara Medical University (2020) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
栗原 都 奈良県立医科大学, 医学部附属病院, 研究員 (40453170)
桐田 忠昭 奈良県立医科大学, 医学部, 教授 (70201465)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 口腔癌 / MIA gene family / 腫瘍マーカー |
Outline of Final Research Achievements |
The MIA gene family functions as a tumor-promoting secreted protein in oral cancer. The applicants have identified STOX2 as a novel downstream signal of MIA. In this study, we identified SERPINE2 and SRPX2 as new secreted proteins related to STOX2, which induce angiogenesis and lymphangiogenesis in oral cancer and are poor prognostic factors. SRPX2 contributes to angiogenesis, lymphangiogenesis, and resistance to anticancer drugs, and is associated with lymph node metastasis and prognosis. Targeting these molecules is expected to be a potential new approach for diagnosis and treatment of oral cancer.
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Free Research Field |
口腔病理学、口腔腫瘍学
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Academic Significance and Societal Importance of the Research Achievements |
口腔癌は進行癌と発見されることが多く、予後不良ながんである。また広範囲にわたる手術を余儀なくされるために、術後の機能や審美性が著しく損なわれ、術後のQOLの低下をもたらすことが少なくない。本研究より、STOX2関連シグナル分子を標的とした新たな口腔癌治診断、治療の可能性が期待される。
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