2022 Fiscal Year Final Research Report
Analysis of the correlation between the novel mfa types of P. gingivalis fimbriae and their functions
| Project/Area Number |
20K09931
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57020:Oral pathobiological science-related
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
内記 良一 愛知学院大学, 歯学部, 講師 (10434622)
三谷 章雄 愛知学院大学, 歯学部, 教授 (50329611)
永野 恵司 北海道医療大学, 歯学部, 教授 (60367620)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Porphyromonas gingivitis / 歯周病原菌 / 線毛 |
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| Outline of Final Research Achievements |
The Mfa1 fimbriae of the periodontal bacterium Porphyromonas gingivalis are composed of Mfa1, Mfa3, Mfa4, and Mfa5 proteins. The major component, encoded by the mfa1 gene, has two genotypes: mfa170 and mfa153. This study demonstrated that mfa170 can be further divided into two antigenically distinct major genotypes, mfa170A and mfa170B.
A few P. gingivalis strains possess tandemly repeated mfa5-like genes within the mfa gene cluster, referred to as mfa5-1 and mfa5-2. This study revealed that Mfa5-2 is a novel protein of Mfa1 fimbriae.
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| Free Research Field |
微生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、新しいmfa1型の分類法が確立されれば、歯周病の症状や重症度との関連性を調査するような臨床研究への発展が期待できる。また、線毛タンパク質と考えられるMfa5-2の働きを阻害することを目的とした新しい創薬開発に繋がる。
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