Simultaneous development of bioactive glass contained pup capping material and localized pulp regenerative biomaterial

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09961
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Kyushu Dental College
• Principal Investigator: Washio Ayako 九州歯科大学, 歯学部, 准教授 (10582786)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: Bioactive glass / FGF-2 / Gelatin / 象牙質・歯髄複合体 / 覆髄材 / 逆根管充填材 / バイオマテリアル / スキャフォールド

Outline of Final Research Achievements

We aimed the development of a pulp capping material containing bioactive glass (BG), which induces wound healing of the dentin-pulp complex. It was found to have good physicochemical properties, cytocompatibility and biocompatibility, leading to the commercialization of BG pulp capping material and its possible application as a retrograde filling material.
In addition, we aimed the developing a BG/FGF2-Gel composite sponge that promotes localized dentin/pulp complex regeneration for exposed pulp where pulp wound healing is difficult to induce by pulp capping. This sponge was found to be a material with high biocompatibility and a mild inflammatory response in terms of dentin/pulp complex wound healing and tissue regeneration.

Free Research Field

バイオマテリアル

Academic Significance and Societal Importance of the Research Achievements

象牙質・歯髄複合体の創傷治癒の創傷治癒と再生を誘導する生体親和性・生体活性のコンセプトを取り入れたバイオマテリアルとして新たな覆髄材，およびスキャフォールドの設計・開発を進めた．それにより，象牙質・歯髄の保存と歯髄の喪失による歯の機能低下の阻止を行うために確実な歯内治療・再生誘導治療を行うことが可能になり，これまで以上に歯の保存・維持，および健全な口腔環境の維持が実現となる.