Molecular characterization and identification of novel therapeutic targets for the therapy-resistant apical periodontitis associated with inflammatory bowel disease.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09970
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Tohoku University
• Principal Investigator: Yahata Yoshio 東北大学, 歯学研究科, 准教授 (30549944)
• Co-Investigator(Kenkyū-buntansha): 齋藤 正寛 東北大学, 歯学研究科, 教授 (40215562) ; 山田 聡 東北大学, 歯学研究科, 教授 (40359849) ; 半田 慶介 神奈川歯科大学, 大学院歯学研究科, 教授 (40433429) ; 野杁 由一郎 新潟大学, 医歯学系, 教授 (50218286)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 炎症性腸疾患 / 根尖性歯周炎 / 治療抵抗性顎骨破壊 / 口腔内炎症性疾患

Outline of Final Research Achievements

Inflammatory bowel disease, in particular, causes a decrease in the immune system not only in the intestine but also in the whole body, and this puts patients at high risk for oral inflammation diseases such as apical periodontitis in the field of dentistry. In this study, we analyzed the inflammatory dynamics of inflammatory bowel disease in a mouse model of inflammatory bowel disease that also suffered from apical periodontitis. The results of this study revealed that the exacerbation of jaw bone destruction caused as a complication of inflammatory bowel disease is caused by the activation of acquired immunity, mainly by Th17 cells.

Free Research Field

歯内療法学

Academic Significance and Societal Importance of the Research Achievements

現在，対応が口腔内局所の炎症制御に終止している，口腔内炎症性疾患に対して，全身との関連による炎症の増悪化を解明した本研究は意義深く，今後の治療戦略として，腸疾患，口腔疾患がそれぞれ独立して介入するのではなく，学際的なアプローチの重要性を説く研究の一端となる．