2022 Fiscal Year Final Research Report
Improvement of success rate of dental implant in menopausal women: Development of novel technology for enhancing bone-implant osseointegration
| Project/Area Number |
20K09996
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57040:Regenerative dentistry and dental engineering-related
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| Research Institution | Shumei University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宍戸 駿一 東北大学, 歯学研究科, 助教 (20850613)
中村 圭祐 東北大学, 歯学研究科, 准教授 (30431589)
神崎 秀嗣 秀明大学, 看護学部, 教授 (60807345)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 歯科インプラント / 骨粗鬆症 / 閉経女性 / 骨結合強度 / ポリフェノール / プロアントシアニジン |
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| Outline of Final Research Achievements |
We tried to assess effects of dietary proanthocyanidin (PA) on osseointegration of dental implants in ovariectomized (OVX) animals. Firstly, PA-containing food pellets were given to OVX rats with dental implants. However, we could not get enough primary fixation of dental implants, so that we failed to assess osseointegration. Secondly, to confirm beneficial effect of dietary PA on bone metabolism, PA-containing food pellets were given to OVX mice. Unlike the gavage administration, bone density was not improved. Lastly, to discuss why dietary PA failed to improve bone metabolism, we intensively surveyed literature. In the case with gavage-administered PA, a large amount of PA could reach the large intestine where PA could exert beneficial effects by interacting with gut microbiota. By contrast, in the case with dietary PA, it is speculated that only a small portion of PA continuously reach the large intestine, resulting in lack of enough interaction with gut microbiota.
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| Free Research Field |
生化学、細胞生物学、生理学、薬理学、歯科学
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| Academic Significance and Societal Importance of the Research Achievements |
プロアントシアニジン (PA) は、これまで更年期モデルとして用いた卵巣摘出動物での強制経口投与試験成績から、高齢の女性の骨粗鬆症予防へ活用できる可能性が示唆されている。しかし、本研究では食事からPAを摂取する場合には、その効果は大幅に減弱する可能性を示唆する成績を得た。従って、PAの骨代謝改善作用を介した閉経期女性の歯科インプラントの骨結合強度改善作用を引き出すには、サプリメントのような形態で摂取する必要があると推察される。今後の研究で課題を明確にし、応用につなげていく。
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