2022 Fiscal Year Final Research Report
Invention of zirconia implant which has a tight attachment towards soft tissue by means of protein immobilization
| Project/Area Number |
20K10021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57040:Regenerative dentistry and dental engineering-related
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | トレシルクロリド / ジルコニア / Y-TZP / 細胞接着タンパク質 / フィブロネクチン / 軟組織付着 / QCM |
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| Outline of Final Research Achievements |
First, two-step protein adsorption was analyzed by using QCM method to improve the soft tissue attachment on zirconia implant. It revealed than the order of protein adsorption influence the following protein adsorption. Next, we did the animal implantation experiments of fibronectin adsorbed zirconia implants. Perpendicularly oriented collage fibers towards zirconia implants were observed in the attached soft tissue. It concluded that fibronectin immobilization was effected to improve the soft tissue attachment.
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| Free Research Field |
歯科理工学
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| Academic Significance and Societal Importance of the Research Achievements |
近年，歯科用インプラントとして，ジルコニアが注目を集めている．本研究では，生体内を模倣した二段階吸着を解析することによって，ジルコニアへのタンパク質に関する新たな知見を得ることができた．また，我々が開発したトレシルクロリド法を用いることによって，ジルコニアに細胞接着タンパク質を固定することができた．軟組織付着能の向上だけではなく，生体反応を制御できる生理活性物質固定化ジルコニアインプラント創製の可能性が期待できる．
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