Development of a novel intentional replantation technique for the reliable regeneration of periodontal ligament

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K10032
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Niigata University
• Principal Investigator: Nagasawa Masako 新潟大学, 医歯学系, 助教 (40612239)
• Co-Investigator(Kenkyū-buntansha): 魚島 勝美 新潟大学, 医歯学系, 教授 (50213400)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 歯根破折 / 歯根膜

Outline of Final Research Achievements

This study aimed to develop a novel intentional replantation technique for regenerating the periodontal ligament at the material's surface. Using various materials used in clinics, induction of cementum cells to the surface of biomaterials, calcification on the surface, and connective tissue attachment were not obtained. Based on these results, methods of mixing growth factors into materials and applying enamel matrix derivative amelogenin (EMD) to the surface of materials were considered. As a result, hard tissue-like tissue was observed on the surface of the filling material in some samples. However, soft tissue also intervened on the surface of the material in those samples. Further study should be needed.

Free Research Field

歯科補綴学

Academic Significance and Societal Importance of the Research Achievements

研究代表者らの研究室では、歯根破折歯修復の臨床研究を行い、歯根破折歯の病因、病態、治療の効果を報告している。しかしながらこの治療の過程で、治療後も残存する局所的な歯周ポケットが長期的に問題となることを認識し、同部位に歯根膜を再生させる方法を模索すべきであると考えた。これによって接着材料の生体内での経年的劣化も防げる可能性が高い。この実現によって、歯根破折修復処置後の患歯の生存率を上げ、患者の咬合崩壊を食い止めることができるため、その社会的意義は大きい。