The investigation of the interrelationship between oral function and systemic health and disease -15 years longitudinal study-

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K10033
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Osaka University
• Principal Investigator: Enoki Kaori 大阪大学, 大学院歯学研究科, 招へい教員 (30632145)
• Co-Investigator(Kenkyū-buntansha): 池邉 一典 大阪大学, 大学院歯学研究科, 教授 (70273696) ; 八田 昂大 大阪大学, 大学院歯学研究科, 招へい教員 (60845949) ; 三原 佑介 大阪大学, 大学院歯学研究科, 助教 (30779096)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 健康長寿 / 口腔機能 / 長期コホート

Outline of Final Research Achievements

It is conjectured that during the aging process, systemic diseases and functional impairments not only affect dental and oral functions, but are also influenced by them, leading both to decline while mutually affecting each other. In this study, we aim to conduct a 15-year cohort study with approximately 600 elderly individuals surveyed every 5 years, to elucidate the bidirectional influences between dental and oral functions, their changes, overall health status, disease incidence, and oral health-related quality of life.
A longitudinal study of about 15 years revealed that the development of gastrointestinal and psychiatric diseases was associated with poor oral function at follow-up, while the development of heart disease, hypertension, and psychiatric diseases was associated with oral-related quality of life at follow-up.

Free Research Field

老年歯科学

Academic Significance and Societal Importance of the Research Achievements

本研究の結果，消化器疾患と精神疾患の発症は口腔機能不良に影響を与える可能性が示された．また，心臓疾患，高血圧および精神疾患の発症は口腔関連QOLに影響を与える可能性が示された．高齢者における全身疾患と口腔機能の相互作用の解明は，口腔と全身の機能低下を抑制する上で重要な役割を示し，医療的にも，医療経済的にも大きな影響を及ぼすことができると考えられる．