2022 Fiscal Year Final Research Report
Development of a comprehensive treatment approach targeting the CXCR4 system and cancer-associated fibroblasts for oral cancer
| Project/Area Number |
20K10095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | CXCR4 / 癌関連線維芽細胞 |
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| Outline of Final Research Achievements |
In the experiment, primary cultures were established from oral cancer cases to obtain cultured CAFs from the tumor region. The effect of an anti-fibrotic drug on the proliferation of CAFs was investigated. As a result, a tendency of growth inhibition in CAFs was observed with pirfenidone. Subsequently, the impact of anti-fibrotic drugs on the cell proliferation of oral cancer cells was examined under CAFs and B88 cell co-culture conditions, but no significant difference in the inhibition of oral cancer cell proliferation was observed. Therefore, these results suggest that the proliferation of oral cancer cells, mediated through the CXCR4 system, is primarily influenced by the growth factors produced by the oral cancer cells themselves, rather than the cancer microenvironment.
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| Free Research Field |
口腔癌
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| Academic Significance and Societal Importance of the Research Achievements |
現在のところ，SDF-1/CXCR4 システムを介した口腔癌におけるCAFs の特性を明らかになっていない．従って，本研究成果での SDF-1/CXCR4 システムを介した口腔癌における CAFs の細胞増殖の影響を明らかにしたことは学術的意義があると考えられる．さらに，CAFs の特性を明らかにすることは，がん患者の生存率向上につながる可能性があり，口腔癌の治療において社会的に意義のある事と思われる．
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