2023 Fiscal Year Final Research Report
Elucidation of the role of the novel osteoclast formation promoting factor Angiogenin in oral cancer bone invasion
| Project/Area Number |
20K10137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐々木 朗 岡山大学, 医歯薬学総合研究科, 特命教授 (00170663)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | Angiogenin |
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| Outline of Final Research Achievements |
Angiogenin (ANG), an angiogenic factor, is produced by various cancer cells and promotes angiogenesis via the receptor Plexin B2 on the surface of vascular endothelial cells. We recently confirmed that ANG is highly expressed in bone invasion areas of oral cancer and that ANG promotes osteoclast formation.
The question that arises from these findings is whether ANG produced by oral cancer cells in the bone microenvironment promotes osteoclast formation and jaw bone destruction. We aim to elucidate this using an oral cancer bone invasion animal model.
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| Free Research Field |
口腔外科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で骨破壊におけるANGの機能を解析することによって，今まで未知であった骨代謝疾患の原因が見つかるかもしれない．また骨粗鬆症の治療法や乳癌や前立腺癌の骨転移の制御へ応用できる．ANG受容体であるPlexinB2は神経軸索ガイダンス因子Semaphorinの受容体でもある．骨微小環境における血管新生と神経新生のクロストークの一部をANGが担っていると考えられ，新たな学術的潮流を作り出せる可能性がある．
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