2023 Fiscal Year Final Research Report
Drug-Selection Standard for Multimodal Analgesia Using Mechanistic Membrane Interactivity Specific to Each Applicable Drug
Project/Area Number |
20K10152
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 57060:Surgical dentistry-related
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Research Institution | Asahi University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
溝上 真樹 社会医療法人厚生会中部国際医療センター(研究支援センター), がん研究部, 研究員 (10231614)
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Project Period (FY) |
2020-04-01 – 2024-03-31
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Keywords | マルチモーダル鎮痛 / 適用薬 / 機序的膜相互作用 / 生体膜 / 膜流動性変化 / 薬物選択基準 / COVID-19 |
Outline of Final Research Achievements |
We studied the membrane interactions of diverse drugs applied to multimodal analgesia in order to gain a new insight into their mechanisms and use the drug structure-specific membrane activity as one of criteria for drug selection. During the COVID-19 pandemic, we could not conduct originally planned experiments and research presentations, therefore, entirely focused on the preliminary experiments for performing a series of studies. Based on their results, we analyzed the biomimetic membrane interactions of acetaminophen in 2021, capsaicin in 2022, and nonsteroidal anti-inflammatory drugs in 2023 by using a fluorescence polarization method. Consequently, we found the possibility that the membrane interactivity is a property common to drugs used in multimodal analgesia and also characterized them based on the membrane interaction-induced changes in membrane fluidity.
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Free Research Field |
薬理学・歯科麻酔学
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Academic Significance and Societal Importance of the Research Achievements |
鎮痛効果を高めるとともに副作用を軽減するために薬物を併用したマルチモーダル鎮痛が、疼痛管理や術後鎮痛に注目されている。しかし、適用薬に対し、科学的根拠に基づく選択法は確立されていない。そこで、薬物選択基準としての利用を目指し、新規作用機序を追究した。生体膜モデル実験から、マルチモーダル鎮痛に現在用いられている全薬物が膜相互作用を示すことを見出した。代表薬:アセトアミノフェン、カプサイシン、非ステロイド系抗炎症薬を比較し、各薬物の膜活性を特徴づけることができた。 コロナ禍の期間、本研究コンセプトがCOVID-19の治療にも応用できる可能性から、COVID-19に関する総説研究へと発展した。
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