Regulation of maxillofacial morphogenesis by histone acetylases.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K10206
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Kyushu University
• Principal Investigator: Terao Fumie 九州大学, 歯学研究院, 助教 (10510018)
• Co-Investigator(Kenkyū-buntansha): 高橋 一郎 九州大学, 歯学研究院, 教授 (70241643) ; 春山 直人 九州大学, 歯学研究院, 准教授 (70359529)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 歯学 / 発生・分化 / ヒストンアセチル化

Outline of Final Research Achievements

We have attempted to elucidate the regulatory mechanisms of maxillofacial patterning during embryonic development. Focusing on epigenetic control mechanisms in the development of the maxillofacial region, we aimed to elucidate the morphological control mechanisms of maxillofacial formation by histone acetyltransferases (HATs).
In cell cultures of cells derived from the embryonic mouse mandibular process and in mandibular process organ cultures, the use of the HAT inhibitor C646 inhibited the development of the mandibular ridge and Meckel's cartilage formation.
This suggests a close involvement of epigenetic regulation in the morphogenesis of the mouse embryonic mandibular process.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

HATの一つであるp300は、マウス胎生期下顎隆起細胞の増殖・分化に深く関わり、下顎隆起の形態形成において、重要な役割を果たしていることが分かった。この結果は、エピジェネティック要因による顎顔面領域における形態形成の制御機構の解明と顎顔面領域における奇形・発育異常などの問題の解決に対して、基盤的知識の蓄積に貢献するものと考えられる。