2023 Fiscal Year Final Research Report

Investigation into the effect of soft-food feeding and neurotransmitter disorders on masticarory and swallowing functions and strategy for prevention of oral frail

Research Project

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Project/Area Number	20K10209
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 57070:Developmental dentistry-related
Research Institution	Nagasaki University
Principal Investigator	Yoshida Noriaki 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (40230750)
Co-Investigator(Kenkyū-buntansha)	吉見知子長崎大学, 病院(歯学系), 医員 (20805973) 藤下あゆみ長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (30755723) 古賀義之長崎大学, 病院(歯学系), 講師 (50175329) 森内絵美長崎大学, 病院(歯学系), 医員 (70866607)
Project Period (FY)	2020-04-01 – 2024-03-31
Keywords	咀嚼 / 嚥下 / 顎運動 / 筋電図
Outline of Final Research Achievements	In order to construct a multidimensional functional analysis system that simultaneously measures biological information such as jaw movement, tongue movement, and muscle activity, we first developed a 6-DOF jaw movement analysis system that combines a high-precision high-speed camera and a 3D micro X-ray CT for animal experiments. By integrating the measured jaw movement function data and the shape measurement data of the mouse cranium, it became possible to calculate the movement of any point on the mandible. This system enabled the measurement of three-dimensional jaw motion at anatomical analysis points inside the body, such as the mandibular head. This enabled visualization of mandibular motion. In addition, it is now possible to analyze in detail the sliding motion of the mandibular head and the grinding and molar grinding motion of food in the molar region.
Free Research Field	歯科矯正学
Academic Significance and Societal Importance of the Research Achievements	本研究の特色は、軟食化の影響や脳内神経伝達物質の咀嚼・嚥下運動制御の役割に着目することで、成長発育に伴う咀嚼・嚥下機能の発達と障害発症機序の解明にブレイクスルーをもたらすものである。本研究により、オーラルフレイルの予防法や診断・治療法の開発に飛躍的な進歩が期待され、国民のQOL向上と健康長寿社会実現に寄与することにも繋がり、社会的波及効果も大きい。咀嚼や嚥下誘発が困難な患者に対して、薬物療法に運動機能療法を併用することにより治療効果を高めることは可能であり、咀嚼・嚥下機能障害の予防や治療にとって極めて画期的である。