2022 Fiscal Year Final Research Report
The novel exploration of the role of primary cilia during tooth development
| Project/Area Number |
20K10211
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 57070:Developmental dentistry-related
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan (2021-2022)
Kyushu Dental College (2020) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中島 由郎 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30455430)
瀬田 祐司 九州歯科大学, 歯学部, 教授 (90291616)
豊野 孝 九州歯科大学, 歯学部, 准教授 (10311929)
片岡 真司 九州歯科大学, 歯学部, 助教 (80364149)
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | 一次繊毛 / 歯胚発生 / 二次口蓋 / 顎下腺管 |
|---|
| Outline of Final Research Achievements |
Inversin (Inv) and Nephrocystin 3 (Nphp3) encode primary cilium related proteins and were expressed in developing mouse tooth germs. Inv and Nphp3 mutant mice exhibited a variety of craniofacial phenotypes such as abnormal shape of the tip of incisors, abnormal erupting direction of incisors, shortened incisors, abnormally lower cusps of molars, cleft palate, and expansion of the duct of submandibular gland. These results suggest that normal functions of Inv and Nphp3 are required for craniofacial development including teeth.
|
| Free Research Field |
顎顔面発生学
|
| Academic Significance and Societal Importance of the Research Achievements |
将来的な歯の再生医療を実現する為には歯の分子設計図としての正常な発生機構の正確な理解が必要不可欠である。本研究の成果によりマウス一次繊毛関連遺伝子であるInvおよびNphp3が切歯や臼歯の正常な形態形成や萌出過程に必須である可能性が示唆された。更にInvは二次口蓋や顎下腺管の正常な形成に関与する可能性が示唆され、顎顔面領域における一次繊毛関連遺伝子の変異を原因とする先天異常発症機構の解明に貢献する成果が得られた。
|
