2022 Fiscal Year Final Research Report
Elucidation of the function of gamma delta T cells that control the migration of osteoclast precursor cells to bone tissue and investigation of the possibility of molecular-targeted agents
| Project/Area Number |
20K10220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57070:Developmental dentistry-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
五十嵐 薫 東北大学, 歯学研究科, 教授 (70202851)
石井 武展 東京歯科大学, 歯学部, 准教授 (80433978)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | γδ T細胞 / マクロファージ遊走阻止因子 / 破骨細胞 / 骨代謝 / 免疫学 |
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| Outline of Final Research Achievements |
The purpose of this study is to elucidate the functions of γδT cells that control both bone resorption and bone formation. Another is to examine the possibility of clinical application to osteoclastic diseases using molecularly targeted agents that target only pathological bone resorption without inhibiting physiological bone remodeling. Each subset of γδ T cell differs in cytokines production and their effects on osteoclasts. Furthermore, the subsets of γδT cells collected from non-inflamed and inflamed tissues were different. It was suggested that these data indicate γδT cells may play an important role in pathological bone resorption and physiological bone remodeling.
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| Free Research Field |
歯科矯正学
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| Academic Significance and Societal Importance of the Research Achievements |
超高齢化社会を迎え、歯周病をはじめとする局所的な骨吸収性疾患や多くの高齢者が抱えている全身的骨代謝関連疾患に対する新たな予防や治療方法は重要な課題の一つと言え、治療手段の選択肢の多様化が求められている。本研究は免疫を司る細胞であるγδT細胞が関与する骨代謝制御のメカニズムを解明し、生理的骨吸収を阻害することなく病的骨吸収のみを対象にした新たな治療選択肢を検討する事を目的とした。γδT細胞が関与する病的骨吸収と生理的骨リモデリングのメカニズムの違いを解明し、病的骨吸収のみをターゲットにした分子標的薬の可能性が示唆された。
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