Elucidation of biomarkers in the relationship between decreased oral function and cancer

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K10243
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57080:Social dentistry-related
• Research Institution: Akita University
• Principal Investigator: Takano Hiroshi 秋田大学, 医学部附属病院, 講師 (30282172)
• Co-Investigator(Kenkyū-buntansha): 福田 雅幸 秋田大学, 医学部附属病院, 准教授 (20272049)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 口腔機能低下 / がん / バイオマーカー

Outline of Final Research Achievements

Oral function in cancer patients was examined and evaluated. At the conference, I presented "A Study on Evaluation of Oral Function in Esophageal Cancer Patients". Patients with esophageal cancer had an increased number of bacteria in the oral cavity, and decreased occlusal strength and swallowing function. Compared to lung cancer patients, patients with esophageal cancer showed a higher prevalence of oral hypofunction. Based on the results of this study, the relationship between esophageal cancer and oral dysfunction was reported in a paper.

Free Research Field

口腔外科

Academic Significance and Societal Importance of the Research Achievements

癌患者と口腔機能低下の関連性についてはこれまで報告がほとんどなく、本研究結果より食道癌患者と口腔機能低下症の関連が認められたことは、今後のがんの発症や予防における口腔関連要素の重要性を示す一助となり、学術的意義が高いものと思われた。また、「口腔機能低下とがんの関連性」におけるバイオマーカーを解明の一端を担うものであり、社会的意義は高いと思われた。