Establishment of reference values by measuring oral VSC for predicting periodontal disease progression

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K10283
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57080:Social dentistry-related
• Research Institution: Matsumoto Dental University
• Principal Investigator: Yamaga Takayuki 松本歯科大学, 歯学部, 教授 (90345512)
• Co-Investigator(Kenkyū-buntansha): 金子 昇 新潟大学, 医歯学総合病院, 講師 (00397126)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 歯周疾患 / 揮発性硫黄化合物 / プレディクタ / 疫学 / リスクファクタ

Outline of Final Research Achievements

The purpose of this study was to establish evidence for the use of volatile sulfur compounds (VSC) as a useful predictor of periodontitis progression.
A questionnaire, oral examinations by a dentists, measurement of VSC concentration, and blood sampling were conducted on 25 hospital employees who consented (including 8 men, average age 34.8 years). carried out. Serum IgG antibody titers (Pg-Ab) against P. gingivalis (P.g.) were measured from blood samples. We investigated the correlation between the concentration of each component of VSC, an index representing the condition of the periodontal tissue, and Pg-Ab, but no significant correlation was found between them.
The results contradicted the working hypothesis that we had set. This is thought to be due to the fact that many subjects had relatively good periodontal tissues and were highly conscious about oral hygiene, and we were unable to obtain samples with various pathological conditions, especially severe periodontitis.

Free Research Field

予防歯科学

Academic Significance and Societal Importance of the Research Achievements

本研究は個人の口腔内VSC濃度の多寡や，それらを構成する各成分の割合が，歯周病原因菌に対する血清抗体価を反映することを作業仮説としたが，歯周疾患の臨床パラメータを含めて相互に有意な相関関係は認められなかった。
しかし，VSCは歯周病原因菌の代謝産物であり歯周疾患の臨床パラメータとの関連も認められなかったことは，既存の先行研究に照らして整合性がとれない。より多様な特性を持った，すなわち歯周疾患の病態が重度なものも含めた対象者の選定が重要であると考えられた。